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Beyond CAR-T: Re-engineering Cells into Life-saving Therapies
Our cells have the innate ability to protect us. The idea of using cells as medicine emerged with bone marrow transplants, and then CAR-T therapy for blood cancers. Now, scientists are beginning to engineer much more complex living therapeutics by…
Transforming Multiple Sclerosis Care Through Precision Medicine
Multiple sclerosis (MS) is a neurological condition where the immune system attacks the nerve fibers thereby affecting the functions of the brain and spinal cord. It affects about 2.8 million people worldwide and leads to symptoms that can vary from…
What’s New in Multiple Myeloma Management?
Multiple myeloma is diagnosed in over 100,000 patients each year worldwide. The FDA recently granted accelerated approval to Teclistamab, the first bispecific B-cell maturation (BCMA)-directed CD3 T-cell engager. The therapeutic armamentarium for myeloma now includes alkylating agents, corticosteroids, deacetylase inhibitors,…
Unraveling the Complexities of BRCA-Related Breast and Ovarian Cancers
The BRCA1 (BReast CAncer gene 1) and BRCA2 are genes that produce proteins crucial for DNA repair. Since these proteins play a pivotal role in cellular resilience against DNA damage — mutations leading to inactivation of these genes results in…
When should people get palliative care?
Palliative care is specialized medical care focused on relieving the symptoms and stress of a serious illness and improving quality of life, in alignment with a patient’s individual goals, values, and priorities. Although palliative care consultation is recommended for millions…